Biotechnology occupies a growing place in the industrialized countries. This place is primarily due to its importance in the domains of agriculture, food and health. This does nothing but make more urgent the necessity for countries in the process of development, for which these domains are vital, to be equipped with necessary means to control this technology. Tunisia has crossed this step by the implementation of a biotechnological plan. This plan is materialized by the creation of the Centre of Biotechnology of Sfax (CBS). The CBS was created by the decree N°83-1037 of November 4, 1983 reorganizing the National Institute of Scientific and Technical Research. Since January 1989, the CBS became an independent institution which budget is attached for order to the state budget. Different other decrees made lead the CBS to its current structure. Law Nº 88-145 of the 31 of December 1988 finance law 1989 art 119. Decree N°98-2411 of the 30 of November 1989 concerning the organization of the Centre of Biotechnology of Sfax . The Prime Minister decree of the 10 of December 1998 concerning the creation of research laboratories in the CBS. The Minister for Scientific Research and Technology of the 19 December 2001 on the creation, the composition and roles of the board of directors and the scientific council of the CBS.